tailieunhanh - Báo cáo khoa học: "Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy. | Pesce et al. Radiation Oncology 2010 5 54 http content 5 1 54 RADIATION ONCOLOGY RESEARCH Open Access Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy Gianfranco A Pesce1 Alessandro Clivio2 Luca Cozzi2 Giorgia Nicolini2 Antonella Richetti1 Emanuela Salati1 Mariacarla Valli1 Eugenio Vanetti2 and Antonella Fogliata 2 Abstract Background To report about initial clinical experience in radiation treatment of carcinoma of prostate with volumetric modulated arcs with the RapidArc RA technology. Methods Forty-five patients with a median age of 72 3 affected by prostate carcinoma T1c 22 patients T2a-b 17 patients T3a-b 6 patients. N0 43 patients N1-Nx 2 patients all M0 with initial PSA of ng mL were treated with RapidArc in a feasibility study. All patients were treated with single arc using 6MV photons. Dose prescription ranged between 76 7 patients and 78 Gy 38 patients in 2Gy fraction. Plan quality was assessed by means of Dose Volume Histogram DVH analysis. Technical parameters of arcs and pre-treatment quality assurance results Gamma Agreement Index GAI are reported to describe delivery features. Early toxicity was scored according to the Common Terminology Criteria of Adverse Effects scale CTCAE scale at the end of treatment together with biochemical outcome PSA . Results From DVH data target coverage was fulfilling planning objectives V95 was in average higher than 98 and V107 D2 in average . Homogeneity D5 -D95 ranged between to . For rectum all planning objectives were largely met . V70Gy against an objective of 25 similarly for bladder . D2 against an objective of . Maximum dose to femurs was D2 against an objective of 47Gy. Monitor Units resulted MU Gy 239 37. Average beam on time was minutes. Pretreatment GAI resulted in . Clinical data were recorded as PSA at 6 weeks after RT with median values of