tailieunhanh - Báo cáo khoa học: "SemiFDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiFDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma. | Krengli et al. Radiation Oncology 2010 5 10 http content 5 1 10 RADIATION ONCOLOGY RESEARCH Open Access FDG-PET CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma 11 31 3 Marco Krengli Maria E Milia Lucia Turri Eleonora Mones Maria C Bassi Barbara Cannillo Letizia Deantonio1 Gianmauro Sacchetti4 Marco Brambilla3 Eugenio Inglese4 Abstract Background FDG-PET CT imaging has an emerging role in staging and treatment planning of various tumor locations and a number of literature studies show that also the carcinoma of the anal canal may benefit from this diagnostic approach. We analyzed the potential impact of FDG-PET CT in stage definition and target volume delineation of patients affected by carcinoma of the anal canal and candidates for curative radiotherapy. Methods Twenty seven patients with biopsy proven anal carcinoma were enrolled. Pathology was squamous cell carcinoma in 20 cases cloacogenic carcinoma in 3 adenocarcinoma in 2 and basal cell carcinoma in 2. Simulation was performed by PET CT imaging with patient in treatment position. Gross Tumor Volume GTV and Clinical Target Volume CTV were drawn on CT and on PET CT fused images. PET-GTV and PET-CTV were respectively compared to CT-GTV and CT-CTV by Wilcoxon rank test for paired data. Results PET CT fused images led to change the stage in 5 27 cases 3 cases from N0 to N2 and 2 from M0 to M1 leading to change the treatment intent from curative to palliative in a case. Based on PET CT imaging GTV and CTV contours changed in 15 27 and in 10 27 cases respectively. PET-GTV and PET-CTV resulted significantly smaller than CT-GTV p X 10-4 and CT-CTV p X 10-4 . PET CT-GTV and PET CT-CTV that were used for clinical purposes were significantly greater than CT-GTV p 6 X 10-5 and CT-CTV p 6 X 10-5 . Conclusions FDG-PET CT has a potential relevant impact in staging and target volume delineation of the carcinoma of the anal canal. .