tailieunhanh - Báo cáo y học: "Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. | Available online http content 8 5 R154 Research article Evidence for chronic peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis James N Jarvis1 Howard R Petty2 Yuhong Tang3 Mark Barton Frank3 Philippe A Tessier4 Igor Dozmorov3 Kaiyu Jiang1 Andrei Kindzelski2 Yanmin Chen1 Craig Cadwell3 Mary Turner3 Peter Szodoray3 Julie L McGhee5 and Michael Centola3 Department of Pediatrics University of Oklahoma College of Medicine 940 Stanton L. Young Blvd. Oklahoma City OK 73104 USA 2Kellogg Eye Center University of Michigan School of Medicine 1000 Wall St. Ann Arbor MI 48105 USA 3Arthritis Immunology Program Oklahoma Medical Research Foundation 820 NE 13th St. Oklahoma City OK 73104 USA 4Centre de Recherche en Infectiologie Centre de Recherche du CHUL 2705 boul. Laurier Ste-Foy Quebec G1V 4G2 Canada 5University of Oklahoma College of Medicine 940 Stanton L. Young Blvd. Oklahoma City OK 731 04 USA Corresponding author James N Jarvis james-jarvis@ Received 17 May 2006 Revisions requested 8 Jun 2006 Revisions received 15 Aug 2006 Accepted 26 Sep 2006 Published 26 Sep 2006 Arthritis Research Therapy 2006 8 R154 doi ar2048 This article is online at http content 8 5 R154 2006 Jarvis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis JRA there remain many aspects of the disease that suggest equally important contributions of the innate immune system. We used gene expression arrays and computer modeling to examine the function in neutrophils of 25 children with .