tailieunhanh - Báo cáo y học: "Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts. | Available online http content 8 5 R152 Open Access Research article Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts Yukiko Komano1 2 Toshihiro Nanki1 Kenji Hayashida3 Ken Taniguchi4 and Nobuyuki Miyasaka1 2 Department of Medicine and Rheumatology Graduate School Tokyo Medical and Dental University Tokyo 113-8519 Japan 2The 21st Century Center of Excellence Program for the Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone Tokyo Medical and Dental University Tokyo 113-8519 Japan 3Department of Orthopedic Surgery Hoshigaoka Koseinenkin Hospital Osaka 573-8511 Japan 4Division of Rheumatic Diseases Tokyo Metropolitan Bokutoh Hospital Tokyo 130-0022 Japan Corresponding author Toshihiro Nanki Received 1 9 May 2006 Revisions requested 13 Jun 2006 Revisions received 25 Aug 2006 Accepted 21 Sep 2006 Published 21 Sep 2006 Arthritis Research Therapy 2006 8 R152 doi ar2046 This article is online at http content 8 5 R152 2006 Komano et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Increased bone resorption mediated by osteoclasts causes various diseases such as osteoporosis and bone erosion in rheumatoid arthritis RA . Osteoclasts are derived from the monocyte macrophage lineage but the precise origin remains unclear. In the present study we show that the purified CD16-human peripheral blood monocyte subset but not the CD16 monocyte subset differentiates into osteoclast by stimulation with receptor activator of NF-kB ligand RANKL in combination with macrophage colony-stimulating factor M-CSF . Integrin-p3 mRNA and the integrin-avp3 heterodimer were only expressed on CD16 .