tailieunhanh - Báo cáo y học: "Response to the commentary ‘Pooled indices to measure rheumatoid arthritis activity: a good reflection of the physician’s mind"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Response to the commentary ‘Pooled indices to measure rheumatoid arthritis activity: a good reflection of the physician’s mind’. | Available online http content 8 6 406 Letter Response to the commentary Pooled indices to measure rheumatoid arthritis activity a good reflection of the physician s mind Bert Vander Cruyssen1 Patrick Durez2 Rene Westhovens3 Nathan Vastesaeger4 Anja Geldhof5 and Filip De Keyser1 Rheumatology Ghent University Hospital Belgium 2Rheumatology Cliniques Universitaires Saint-Luc Brussels Belgium 3Rheumatology University Hospitals KULeuven Leuven Belgium 4Medical affaires Schering Plough Brussels Belgium 5Medical affaires Centocor Leiden the Netherlands Corresponding author Bert Vander Cruyssen Published 10 October 2006 Arthritis Research Therapy 2006 8 406 doi ar2044 This article is online at http content 8 6 406 2006 BioMed Central Ltd See related commentary by Aletaha http content 8 1 102 related research article by Vander Cruyssen et al. http content 7 5 R1063 and related commentary by van Riel and Fransen http content 7 5 189 The February issue of Arthritis Research Therapy included a commentary by Aletaha 1 on a recent report from our group 2 . First Aletaha states that evaluation of the physician s mind is best performed in a study setting in which the physician is unaware that their clinical decision is part of the investigation. It should be noted that the analysis we reported 2 was a post hoc analysis on a cohort of patients with rheumatoid arthritis RA who began infliximab therapy within the context of an expanded access programme and in which infliximab therapy was provided for free until reimbursement in 2002. In the initial protocol it was pre-specified that from week 30 onward patients with insufficient response to the therapy could receive an extra vial at each infusion. This decision had to be taken at week 22 and was based on the treating rheumatologist s appreciation of the patient s condition and disease