tailieunhanh - Báo cáo y học: "Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulatio"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. | Available online http content 8 5 R149 Research article Decreased metalloproteinase production as a response to mechanical pressure in human cartilage a mechanism for homeostatic regulation Jordi Monfort1 Natalia Garcia-Giralt1 María J Lopez-Armada2 Joan C Monllau1 Angeles Bonilla2 Pere Benito1 and Francisco J Blanco2 Open Access 1Unitat de recerca en fisiopatologia òssia i articular- Institut Municipal d Investigacio Mèdica URFOA-IMIM Hospital del Mar Universitat Autònoma de Barcelona Dr. Aiguader 80 08003-Barcelona Spain 2Osteoarticular and Aging Research Unit Rheumatology Division Biomedical Researcher Center Complejo Hospitalario Universitario Juan Canalejo Xubias 84 15006 - A Coruna Spain Corresponding author Francisco J Blanco fblagar@ Received 11 Apr 2006 Revisions requested 9 Jun 2006 Revisions received 8 Aug 2006 Accepted 14 Sep 2006 Published 14 Sep 2006 Arthritis Research Therapy 2006 8 R149 doi ar2042 This article is online at http content 8 5 R149 2006 Monfort et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Articular cartilage is optimised for bearing mechanical loads. Chondrocytes are the only cells present in mature cartilage and are responsible for the synthesis and integrity of the extracellular matrix. Appropriate joint loads stimulate chondrocytes to maintain healthy cartilage with a concrete protein composition according to loading demands. In contrast inappropriate loads alter the composition of cartilage leading to osteoarthritis OA . Matrix metalloproteinases MMPs are involved in degradation of cartilage matrix components and have been implicated in OA but their role in loading response is unclear. With this study we .