tailieunhanh - Báo cáo y học: "Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy study. | Available online http content 8 5 R147 Open Access Research article Long-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner an infrared microspectroscopic imaging and polarized light microscopy study Ehsan Saadat1 Howard Lan1 Sharmila Majumdar1 2 David M Rempel1 3 and Karen B King1 3 4 Department of Bioengineering University of California Berkeley 459 Evans Hall 1762 Berkeley CA 94720-1762 USA 2Department of Radiology University of California San Francisco 1 700 4th Street Suite 203 Box 2520 San Francisco CA 94107 USA 3Department of Medicine Division of Occupational Medicine University of California San Francisco Building 30 5th floor San Francisco General Hospital 1001 Potrero Avenue San Francisco CA 94110 USA 4Department of Orthopaedics Division of Bioengineering University of Colorado at Denver and Health Sciences Center 12800 E. 1 9th Ave. RC1 N Room 2103 Mailstop 8343 PO Box 6511 Aurora CO 80045 USA Corresponding author Karen B King Received 16 Jun 2006 Revisions requested 27 Jul 2006 Revisions received 18 Aug 2006 Accepted 6 Sep 2006 Published 6 Sep 2006 Arthritis Research Therapy 2006 8 R147 doi ar2040 This article is online at http content 8 5 R147 2006 Saadat et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Understanding the changes in collagen and proteoglycan content of cartilage due to physical forces is necessary for progress in treating joint disorders including those due to overuse. Physical forces in the chondrocyte environment can affect the cellular processes involved in the biosynthesis of extracellular matrix. In turn the biomechanical properties of cartilage depend