tailieunhanh - Báo cáo y học: "Safety concerns on the development of novel therapeutic drugs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Safety concerns on the development of novel therapeutic drugs. | Available online http content 8 5 112 Commentary Safety concerns on the development of novel therapeutic drugs Caroline Ospelt and Steffen Gay Center of Experimental Rheumatology Zurich Switzerland Corresponding author Caroline Ospelt Published 1 September 2006 This article is online at http content 8 5 112 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 112 doi ar2032 Abstract Along with recent innovative approaches resulting in the development of new therapies such as small molecular inhibitors therapeutic antibodies recombinant proteins and gene therapy there is increasing need for improved understanding of the basic molecular mechanisms that are exploited by such treatments. Helpful tools in the analysis of drug effects include high-throughput screening techniques such as microarrays which are used in transcriptomics and pharmacogenomics. Although we are far from using these extensive and costly tests in our daily clinical routine their application in basic research nevertheless takes us closer to individualized therapeutic strategies in which the optimal therapeutic regimen is identified for each individual patient. With the current trend toward development of specific molecular targeted therapies the translation of basic science research to clinical medicine is more important than ever. However it is similarly important to take a step back from the bedside to the bench. In the development process new therapeutic substances are extensively tested in vitro and in animal and clinical studies. These tests thoroughly describe the pharmacological and toxicological properties of the drug but they often fail to grasp the complex effects of a drug on its target cells. In many cases unexpected negative but also positive effects of a substance are only revealed after longer term clinical use. In this commentary we highlight some possible approaches to analyzing the properties of a .