tailieunhanh - Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures. | Available online http content 8 5 R140 Research article Serum urinary and salivary nitric oxide in rheumatoid arthritis complexities of interpreting nitric oxide measures J Brice Weinberg1 2 Thomas Lang3 William E Wilkinson2 David S Pisetsky1 2 and E William St Clair2 Veterans Affairs Medical Center 508 Fulton Street Durham NC 27705 USA 2Duke University Medical Center 508 Fulton Street Durham NC 27705 USA 3University of Maryland School of Medicine 10 South Pine Street Baltimore MD USA 21201 Corresponding author J Brice Weinberg brice@ Received 1 Jun 2006 Revisions requested 19 Jul 2006 Revisions received 30 Jul 2006 Accepted 14 Aug 2006 Published 14 Aug 2006 Arthritis Research Therapy 2006 8 R140 doi ar2030 This article is online at http content 8 5 R140 2006 Weinberg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Nitric oxide NO may play important roles in rheumatoid arthritis RA . RA is an inflammatory disease involving joints and other systems including salivary glands. To assess NO production in RA patients we compared levels of serum urine and salivary nitrite and nitrate NOx in patients with RA and normal subjects and we examined the relationships of these measures to disease activity. Serum urine and NOx levels as well as renal creatinine NOx clearance and fractional excretion rates were compared in 25 RA patients and 20 age- and gender-matched healthy controls. Subjects were hospitalized for 3 days and placed on a NOxrestricted diet. NOx was assayed using nitrate reductase and the Griess reagent. RA activity was assessed using standard clinical and laboratory measures. While consuming a restricted diet for 3 days to eliminate