tailieunhanh - Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. | Available online http content 8 5 R139 Research article Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury Francesco Dell Accio1 Cosimo De Bari1 Noha MF El Tawil1 Francesca Barone1 Thimios A Mitsiadis2 John O Dowd3 and Costantino Pitzalis1 Open Access Department of Rheumatology King s College London London UK department of Craniofacial Development King s College London London UK 3Guy s and St Thomas s Hospitals London UK Corresponding author Francesco Dell Accio Received 17 Feb 2006 Revisions requested 4 Apr 2006 Revisions received 2 May 2006 Accepted 7 Aug 2006 Published 7 Aug 2006 Arthritis Research Therapy 2006 8 R139 doi ar2029 This article is online at http content 8 5 R139 2006 Dell Accio et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Acute full thickness joint surface defects can undergo repair which involves tissue patterning and endochondral bone formation. Molecular signals regulating this process may contribute to the repair outcome chronic evolution and eventually the onset of osteoarthritis. We tested the hypothesis that mechanical injury modulates morphogenetic pathways in adult human articular cartilage explants. Adjacent articular cartilage explants were obtained from preserved areas of the femoral condyles of patients undergoing arthroplasty for osteoarthritis or from a normal joint of a patient undergoing lower limb amputation. Paired explants were individually maintained in explant culture. From each pair one explant was mechanically injured and the other left uninjured as a control. Cultures were terminated at different time points for histochemistry .