tailieunhanh - Báo cáo khoa học: " Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma. | Wernicke et al. Radiation Oncology 2010 5 46 http content 5 1 46 RADIATION ONCOLOGY SHORT REPORT Open Access Assessment of Epidermal Growth Factor Receptor EGFR expression in human meningioma A Gabriella Wernicke 1 Adam P Dicker2 Michal Whiton2 Jana Ivanidze3 Terry Hyslop4 Elizabeth H Hammond5 Arie Perry6 David W Andrews7 and Lawrence Kenyon8 Abstract Purpose This study explores whether meningioma expresses epidermal growth factor receptor EGFR and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression. Methods Following institutional review board approval 113 meningioma specimens from 89 patients were chosen. Of these 85 were used for final analysis. After a blinded review immunohistochemical stains for EGFR were performed. Staining intensity SI was scored on a scale 0-3 from no staining to strong staining . Staining percentage of immunoreactive cells SP was scored 1-5 from the least to the maximum percent of the specimen staining . Immunohistochemical score IHS was calculated as the product of SI and SP Results Eighty-five samples of meningioma were classified in accordance with World Health Organization WHO criteria benign 57 85 67 atypical 23 85 27 and malignant 5 85 6 . The majority of samples demonstrated a moderate SI for EGFR. IHS for EGFR demonstrated a significant association between SI and histopathologic subtype. Also there was a correlation between the SP and histopathologic subtype p . A significant association was determined when the benign and the atypical samples were compared to the malignant with respect to the SP p . While there was a range of the IHS for the benign and the atypical histologic subtypes malignant tumors exhibited the lowest score and were statistically different from the benign and the atypical specimens p . Conclusions To our knowledge this represents the largest series of meningioma samples analyzed for EGFR expression reported in the .

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