tailieunhanh - Báo cáo y học: "Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene. | Available online http content 8 4 R135 Research article Prostaglandin E2 synthesis in cartilage explants under compression mPGES-1 is a mechanosensitive gene Marjolaine Gosset1 Francis Berenbaum1 2 Arlette Levy1 Audrey Pigenet1 Sylvie Thirion3 JeanLouis Saffar4 and Claire Jacques1 1UMR 7079 CNRS Physiology and Physiopathology Laboratory University Paris 6 quai St-Bernard Paris 75252 Cedex 5 France 2Department of Rheumatology UFR Pierre et Marie Curie Saint-Antoine Hospital 7501 2 Paris France 3CNE Neuroendocrine Cellular Interactions UMR CNRS 6544 Mediterranean University Faculty of Medecine 13916 Marseille Cedex 20 France 4Laboratory on Oro-facial Repair and Replannings EA 2496 University Paris Descartes Faculty of Odontology 92120 Montrouge France Corresponding author Francis Berenbaum Received 21 Feb 2006 Revisions requested 6 Apr 2006 Revisions received 5 Jul 2006 Accepted 27 Jul 2006 Published 27 Jul 2006 Arthritis Research Therapy 2006 8 R135 doi ar2024 This article is online at http content 8 4 R135 2006 Gosset et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Knee osteoarthritis OA results at least in part from overloading and inflammation leading to cartilage degradation. Prostaglandin E2 PGE2 is one of the main catabolic factors involved in OA. Its synthesis is the result of cyclooxygenase COX and prostaglandin E synthase PGES activities whereas NAD -dependent 15 hydroxy prostaglandin dehydrogenase 15-PGDH is the key enzyme implicated in the catabolism of PGE2. For both COX and PGES three isoforms have been described in cartilage COX-1 and cytosolic PGES are constitutively expressed whereas COX-2 .