tailieunhanh - Báo cáo y học: "Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. | Available online http content 8 4 R132 Research article Macrophage migration inhibitory factor a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis Angela Pakozdi1 Mohammad A Amin1 Christian S Haas1 Rita J Martinez1 G Kenneth Haines 3rd2 Lanie L Santos3 Eric F Morand3 John R David4 and Alisa E Koch1 5 Open Access 1 University of Michigan Medical School 109 Zina Pitcher Place Ann Arbor MI 48109 USA 2Northwestern University Feinberg School of Medicine 251 E. Huron Street Chicago IL 60611 USA 3Monash University Department of Medicine Monash Medical Centre Locked Back No 29 Clayton VIC 31 68 Australia 4Harvard School of Public Health Boston 665 Huntington Avenue Boston MA 02115 USA 5VA Medical Service Department of Veterans Affairs 2215 Fuller Road Ann Arbor MI 48105 USA Corresponding author Alisa E Koch aekoch@ Received 22 Feb 2006 Revisions requested 23 May 2006 Revisions received 19 Jun 2006 Accepted 26 Jul 2006 Published 26 Jul 2006 Arthritis Research Therapy 2006 8 R132 doi ar2021 This article is online at http content 8 4 R132 2006 Pakozdi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Rheumatoid arthritis RA is a chronic inflammatory disease characterized by destruction of bone and cartilage which is mediated in part by synovial fibroblasts. Matrix metalloproteinases MMPs are a large family of proteolytic enzymes responsible for matrix degradation. Macrophage migration inhibitory factor MIF is a cytokine that induces the production of a large number of proinflammatory molecules and has an important role in the pathogenesis of RA by promoting inflammation and angiogenesis. In the present study we determined the role