tailieunhanh - Báo cáo y học: "Genetic aspects of fibromyalgia syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic aspects of fibromyalgia syndrome. | Available online http content 8 5 218 Review Biology and therapy of fibromyalgia Genetic aspects of fibromyalgia syndrome Dan Buskila1 and Piercarlo Sarzi-Puttini2 1 Department of Medicine H Soroka Medical Center and Faculty of Health Sciences Ben Gurion University Beer Sheva Israel 2Department of Rheumatology University Hospital L. Sacco Milan Italy Corresponding author Dan Buskila dbuskila@ Published 28 July 2006 This article is online at http eontent 8 5 218 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 218 doi ar2005 Abstract Genetic and environmental factors may play a role in the etio-pathology of fibromyalgia syndrome FMS and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic dopaminergic and catecholaminergic systems play a role in the etiology of FMS. These polymorphisms are not specific for FMS and are associated with other functional somatic disorders and depression. Future genetic studies in the field of FMS and related conditions should be conducted in larger cohorts of patients and ethnically matched control groups. Introduction Fibromyalgia is an idiopathic chronic pain syndrome defined by widespread nonarticular musculoskeletal pain and generalized tender points 1 . Fibromyalgia syndrome FMS overlaps with several related syndromes the functional somatic syndromes 2 . The pathogenesis of FMS and related conditions is not entirely understood although the current concept views FMS as the result of central nervous system malfunction resulting in amplification of pain transmission and interpretation 3 4 . Recent evidence suggests that FMS and related syndromes share heritable pathophysiological features 5 6 . Certain environmental factors may trigger the development of FMS and related conditions in .