tailieunhanh - Báo cáo y học: "Shining light on lupus and UV"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Shining light on lupus and UV. | Available online http content 9 1 101 Editorial Shining light on lupus and UV Melanie K Kuechle1 and Keith B Elkon2 1 Division of Dermatology University of Washington School of Medicine NE Pacific Street Seattle WA 98195 USA 2Division of Rheumatology University of Washington School of Medicine NE Pacific Street Seattle WA 98195 USA Corresponding author Keith B Elkon elkon@ Published 18 January 2007 Arthritis Research Therapy 2007 9 101 doi ar2100 This article is online at http content 9 1 101 2007 BioMed Central Ltd See related research by Reefman et al. http content 8 6 R156 Abstract People exposed to sunlight can develop erythema DNA damage and photoimmunosupression. Extended exposure of normal epidermis to sunlight will induce dysmorphic keratinocytes with pyknotic nuclei scattered throughout the spinous layer. These sunburn cells are apoptotic keratinocytes and are usually cleared within 48 hours after sunburn. Patients with lupus erythematosus however whether it be the discoid subacute cutaneous systemic or tumid form develop new cutaneous lesions and can experience systemic worsening of their disease. Are sunlight-induced keratinocyte apoptosis and the immune response to these cells abnormal in lupus patients This commentary examines the question of whether sunlight-induced keratinocyte apoptosis and the immune response to these cells are abnormal in lupus patients in the context of the study by Reefman and colleagues 1 which evaluates induction and clearance of apoptotic keratinocytes in lupus skin. The response of normal keratinocytes to UV light is well documented and includes activation of signaling molecules that modify growth to allow time for DNA repair 2 . If the keratinocyte incurs irreparable damage apoptosis ensues generating sunburn cells in the epidermis 3 . Unlike macrophage-rich organs such as the thymus or spleen the epidermis contains only Langerhans