tailieunhanh - Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases. | Available online http content 8 4 R111 Open Access Research article Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases Yoshioki Yamasaki1 Sonali Narain1 Liza Hernandez1 Tolga Barker1 Keigo Ikeda3 Mark S Segal4 Hanno B Richards1 2 Edward KL Chan3 Westley H Reeves1 2 and Minoru Satoh1 2 Division of Rheumatology and Clinical Immunology Department of Medicine University of Florida PO Box 100221 Gainesville Florida 32610 USA 2Department of Pathology Immunology and Laboratory Medicine University of Florida PO Box 100221 Gainesville Florida 32610 USA 3Department of Oral Biology University of Florida PO Box 1 00424 Gainesville Florida 32610 USA 4Division of Nephrology Department of Medicine University of Florida PO Box 100221 Gainesville Florida 32610 USA Corresponding author Minoru Satoh satohm@ Received 19 Apr 2006 Revisions requested 10 May 2006 Revisions received 14 Jun 2006 Accepted 28 Jun 2006 Published 1 7 Jul 2006 Arthritis Research Therapy 2006 8 R111 doi ar2000 This article is online at http content 8 4 R111 2006 Yamasaki et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Replication protein A RPA a heterotrimer with subunits of molecular masses 70 32 and 14 kDa is a single-stranded-DNA-binding factor involved in DNA replication repair and recombination. There have been only three reported cases of anti-RPA in systemic lupus erythematosus SLE and Sjogren syndrome SjS . This study sought to clarify the clinical significance of autoantibodies against RPA. Sera from 1 119 patients enrolled during the period 2000 to 2005 were screened by immunoprecipitation IP of 35S-labeled .