tailieunhanh - Báo cáo y học: "A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis. | Available online http content 8 4 R113 Research article A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis James M Woods1 Karolina Klosowska1 Darrin J Spoden1 Nataliya G Stumbo1 Douglas J Paige1 John C Scatizzi2 Michael V Volin1 Malathi S Rao1 and Harris Perlman2 Open Access Department of Microbiology and Immunology Chicago College of Osteopathic Medicine Midwestern University Downers Grove IL 60515 USA department of Molecular Microbiology-Immunology Saint Louis University School of Medicine St Louis MO 631 04 USA Corresponding author James M Woods JWoods@ Received 2 Feb 2006 Revisions requested 6 Mar 2006 Revisions received 2 Jun 2006 Accepted 27 Jun 2006 Published 17 Jul 2006 Arthritis Research Therapy 2006 8 R113 doi ar1999 This article is online at http content 8 4 R113 2006 Woods et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Rheumatoid arthritis RA is characterized by synovial hyperplasia and destruction of cartilage and bone. The fibroblast-like synoviocyte FLS population is central to the development of pannus by migrating into cartilage and bone. We demonstrated previously that expression of the cell cycle inhibitor p21 is significantly reduced in RA synovial lining particularly in the FLS. The aim of this study was to determine whether reduced expression of p21 in FLS could alter the migratory behavior of these cells. FLS were isolated from mice deficient in p21 p21 - - and were examined with respect to growth and migration. p21 and wild-type WT FLS were compared with respect to migration towards chemoattractants found in RA synovial fluid in the presence and absence of cell .