tailieunhanh - Báo cáo y học: "Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. | Available online http content 8 4 R109 Research article Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis Ann W Morgan1 Jim I Robinson1 Jennifer H Barrett1 Javier Martin2 Amy Walker1 Sarah J Babbage1 William ER Ollier3 Miguel A Gonzalez-Gay4 and John D Isaacs1 5 1Leeds Institute for Molecular Medicine University of Leeds Leeds UK 2Instituto de Parasitología y Biomedicina López Neyra CSIC Granada Spain 3The Centre for Integrated Genomic Medical Research The University of Manchester Manchester UK 4Rheumatology Division Hospital Xeral-Calde Lugo Spain 5School of Clinical Medical Sciences Rheumatology University of Newcastle-Upon-Tyne UK Corresponding author Ann W Morgan Received 19 Dec 2005 Revisions requested 19 Jan 2006 Revisions received 19 Jun 2006 Accepted 22 Jun 2006 Published 17 Jul 2006 Arthritis Research Therapy 2006 8 R109 doi ar1996 This article is online at http content 8 4 R109 2006 Morgan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The Fc gamma receptors have been shown to play important roles in the initiation and regulation of many immunological and inflammatory processes and to amplify and refine the immune response to an infection. We have investigated the hypothesis that polymorphism within the FCGR genetic locus is associated with giant cell arteritis GCA . Biallelic polymorphisms in FCGR2A FCGR3A FCGR3B and FCGR2B were examined for association with biopsy-proven GCA n 85 and healthy ethnically matched controls n 132 in a well-characterised cohort from Lugo Spain. Haplotype frequencies and linkage disequilibrium O were estimated across the FCGR locus and a