tailieunhanh - Báo cáo y học: "Replication of association of the D-repeat polymorphism in asporin with osteoarthristis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Replication of association of the D-repeat polymorphism in asporin with osteoarthristis. | Available online http content 8 4 403 Letter Replication of association of the D-repeat polymorphism in asporin with osteoarthristis Shiro Ikegawa1 Shingo Kawamura1 Atsushi Takahashi2 Takahiro Nakamura2 and Naoyuki Kamatani2 1 Laboratory for Bone and Joint Diseases SNP Research Center RIKEN 4-6-1 Shirokanedai Minato-ku Tokyo 108-8639 Japan 2Laboratory for Statistical Analysis SNP Research Center RIKEN 4-6-1 Shirokanedai Minato-ku Tokyo 108-8639 Japan Corresponding author Shiro Ikegawa sikegawa@ Published 29 June 2006 Arthritis Research Therapy 2006 8 403 doi ar1992 This article is online at http content 8 4 403 2006 BioMed Central Ltd See related research by Rodriguez-Lopez et al. http content 8 3 R55 Rodriguez-Lopez and colleagues 1 describe a replication study of our previous association between osteoarthritis OA and asporin 2 . The authors were unable to find this association in the Spanish population and question the association we found in the Japanese population. Their report also contains an interpretation of two previous papers on the same topic 3 4 that differs from those of the original study authors. We have concerns about their interpretation of data and about the conclusions drawn. It is not surprising that an association of a gene with a disease is found in some populations but not in others. Such diversity has been established for many common complex diseases with several explanations 5 . In this particular case one explanation is the difference in the inclusion criteria used to recruit study participants. Whereas we recruited symptomatic OA patients with supporting radiographic evidence Rodriguez-Lopez and colleagues used joint replacement surgery as inclusion criteria Table 1 . Another explanation is ethnic diversity which is apparent in the very different allelic frequencies between the Spanish and Japanese populations. We question the authors .