tailieunhanh - Báo cáo y học: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis"
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis. | Available online http content 8 4 R105 Research article Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis Thierry Lequerré1 2 3 4 Anne-Christine Gauthier-Jauneau1 2 3 Carine Bansard2 3 Céline Derambure1 2 3 Martine Hiron2 3 4 Olivier Vittecoq1 2 3 4 Maryvonne Daveau2 3 4 Othmane Mejjad1 Alain Daragon1 Frangois Tron2 3 4 Xavier Le Loet1 2 3 4 and Jean- Philippe Salier2 3 4 1CHU de Rouen Hôpitaux de Rouen Service de Rhumatologie Rouen F-76000 France 2Inserm U519 Rouen F-76000 France 3Université Rouen Faculté de Médecine-Pharmacie Institut Fédératif de Recherche Multidisciplinaire sur les Peptides Rouen F-76000 France 4Consortium EGERIE Rouen Paris France Corresponding author Jean-Philippe Salier Received 28 Mar 2006 Revisions requested 16 May 2006 Revisions received 23 May 2006 Accepted 8 Jul 2006 Published 3 Jul 2006 Arthritis Research Therapy 2006 8 R105 doi ar1990 This article is online at http content 8 4 R105 2006 Lequerré et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract As indicators of responsiveness to a tumour necrosis factor TNF a blocking agent infliximab are lacking in rheumatoid arthritis we have used gene profiling in peripheral blood mononuclear cells to predict a good versus poor response to infliximab. Thirty three patients with very active disease Disease Activity Score 28 that resisted weekly methotrexate therapy were given infliximab at baseline weeks 2 and 6 and every 8th week thereafter. The patients were categorized as responders if a change of Disease Activity Score 28 was obtained at 3 months. Mononuclear cell RNAs were collected at .
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