tailieunhanh - Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations. | Available online http content 8 4 R101 Research article Contribution of KIR3DL1 3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations Carlos Lopez-Larrea1 Miguel Angel Blanco-Gelaz1 Juan Carlos Torre-Alonso2 Jacome Bruges Armas3 Beatriz Suarez-Alvarez1 Laura Pruneda1 Ana Rita Couto3 Segundo Gonzalez4 Antonio Lopez-Vazquez1 and Jesus Martinez-Borra1 Open Access Histocompatibility and Transplantation Unit Hospital Universtario Central de Asturias Celestino Villamil s n. 33006 Oviedo Asturias Spain 2Rheumatology Unit Hospital Monte Naranco Avda Dres Fernandez Vega 107. 3301 2 Oviedo Asturias Spain 3Immunogenetic Service Hospital de Santo Espirito de Angra do Heroismo Vinha Brava. 9700 Angra do Heroismo Azores Portugal 4Functional Biology Department University of Oviedo Avda Julian Claveria s n. 33006 Oviedo Asturias Spain Corresponding author Carlos Lopez-Larrea inmuno@ Received 10 Mar 2006 Revisions requested 23 Mar 2006 Revisions received 5 Apr 2006 Accepted 5 Jun 2006 Published 28 Jun 2006 Arthritis Research Therapy 2006 8 R101 doi ar1988 This article is online at http content 8 4 R101 2006 Lopez-Larrea et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Killer cell immunoglobulin-like receptors KIRs and human leukocyte antigen HLA loci are both highly polymorphic and some HLA class I molecules bind and trigger cell-surface receptors specified by KIR genes. We examined whether the combination of KIR3DS1 3DL1 genes in concert with HLA-B27 genotypes is associated with susceptibility to ankylosing spondylitis AS . Two HLA-B27-positive Caucasian populations were selected one from Spain 71 patients and 105 controls and another .