tailieunhanh - Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The RNA interference pathway: a new target for autoimmunity. | Available online http content 8 4 110 Commentary The RNA interference pathway a new target for autoimmunity Ger JM Pruijn Department of Biochemistry Radboud University Nijmegen Nijmegen The Netherlands Corresponding author Ger JM Pruijn Published 22 June 2006 Arthritis Research Therapy 2006 8 110 doi ar1987 This article is online at http content 8 4 110 2006 BioMed Central Ltd See related research article by Jakymiw et al. http content 8 4 R87 Abstract Many intracellular macromolecular complexes that are involved in the production or degradation of RNAs are targeted by autoantibodies in systemic autoimmune diseases. RNA interference RNAi is a recently characterized gene silencing pathway by which specific mRNAs are either degraded or translationally suppressed. In a recent issue of Arthritis Research and Therapy Andrew Jakymiw and colleagues reported that the enigmatic Su autoantigen complex contains key components of the RNAi machinery. Anti-Su autoantibodies from both human patients with rheumatic diseases and a mouse model of autoimmunity recognize the endonucleolytic Argonaute and Dicer proteins both crucial enzymes of the RNAi pathway. These data raise the question of how the anti-Su response is triggered. So far it is unknown whether molecular modifications may be involved as has been proposed for other intracellular autoantigens. The implication of RNAi in anti-viral defence may suggest a role for virus infection in this process. Many key regulators of gene expression were previously shown to be targeted by the immune system in a variety of autoimmune diseases. Patients with systemic autoimmune diseases commonly produce antibodies against specific classes of evolutionarily conserved nucleic acid-protein complexes. Most frequently the targeted proteins are either RNA-binding themselves or associated with RNA-binding proteins rather than proteins associated with .