tailieunhanh - Báo cáo y học: "NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. | Available online http content 8 4 R104 Research article NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis contribution to the transcriptional activity Yasushi Kawaguchi1 Akiko Tochimoto1 Masako Hara1 Manabu Kawamoto1 Tomoko Sugiura1 Yasuhiro Katsumata1 Jun Okada2 Hirobumi Kondo2 Mitsuo Okubo3 and Naoyuki Kamatani1 institute of Rheumatology Tokyo Women s Medical University Tokyo Japan 2Department of Internal Medicine Kitasato University School of Medicine Sagamihara Japan 3Transfusion Medicine and Cell Therapy Saitama Medical School Kawagoe Japan Corresponding author Yasushi Kawaguchi y-kawa@ Received 22 Feb 2006 Revisions requested 27 Apr 2006 Revisions received 14 May 2006 Accepted 2 Jun 2006 Published 3 Jul 2006 Arthritis Research Therapy 2006 8 R104 doi ar1984 This article is online at http content 8 4 R104 2006 Kawaguchi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Systemic sclerosis SSc is a connective tissue disease characterized by tissue fibrosis. One of several complications of SSc pulmonary arterial hypertension PAH can be refractory to treatment both novel and established. In the present study we investigated the ratio of circulating nitric oxide to endothelin-1 in patients with both SSc and PAH and determined whether polymorphisms in NOS2 the nitric oxide synthase 2 gene are associated with susceptibility to PAH. Endothelin-1 in plasma and nitric oxide metabolites nitrate and nitrite in serum were measured. The nitric oxide endothelin-1 ratio was significantly lower in patients with both SSc and PAH than in patients with SSc only or in healthy control .