tailieunhanh - Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. | Available online http content 8 3 R70 Research article The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis Zhenxin Shen1 Tania N Crotti1-2 Kevin P McHugh1 2 Kenichiro Matsuzaki1 Ellen M Gravallese1 Benjamin E Bierbaum3 and Steven R Goldring1 1New England Baptist Bone and Joint Institute Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA 2Department of Orthopaedic Surgery Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA 3Department of Orthopedics New England Baptist Hospital Boston Massachusetts USA Corresponding author Steven R Goldring sgoldrin@ Received 17 Jan 2006 Revisions requested 15 Feb 2006 Revisions received 22 Feb 2006 Accepted 14 Mar 2006 Published 13 Apr 2006 Arthritis Research Therapy 2006 8 R70 doi ar1 938 This article is online at http content 8 3 R70 2006 Shen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition wear particles released from the implant components induce a granulomatous inflammatory reaction at the interface between implant and adjacent bone leading to progressive bone resorption and loss of fixation. The present study was undertaken to characterize definitively the phenotype of osteoclast-like cells associated with regions of peri-implant focal bone resorption and to compare the phenotypic features of these cells with those of mononucleated and multinucleated cells associated with polyethylene wear particles. Peri-implant tissues