tailieunhanh - Endocrinology Basic and Clinical Principles - part 5

Sau đó, các nghiên cứu tương tự được tiến hành ở đó chồn được điều trị bằng indoleamine này. Kết quả của những nghiên cứu này xác nhận rằng melatonin, khi được dùng như một cấy ghép để chồn trong suốt mùa hè, gây rụng lông của lông vào mùa hè và tăng trưởng đầu tiên | 168 Part III Insects Plants Comparative until Wisconsin researchers demonstrated that melatonin implanted into another mustelid the short-tailed weasel forced molting of their brown summer fur and the growth of white winter fur. Subsequently similar studies were conducted in which mink were treated with this indoleamine. The results of these studies confirmed that melatonin when administered as an implant to mink during the summer induced molting of the summer fur and early growth of winter pelage. This seasonal effectiveness of melatonin became obvious once it was demonstrated that in all vertebrate species examined thus far the concentrations of melatonin in the pineal gland and plasma are increased during the dark portion of the daily light dark cycle. It is now well established that the nocturnal rise in melatonin production occurs because norepinephrine released from innervating sympathetic neurons binds to pinealocyte P-adren-ergic receptors resulting in cAMP-mediated induction of A-acetyltransferase the rate-limiting enzyme in the biochemical pathway leading to melatonin synthesis. Thus as summer turns to fall the average daily endogenous levels of melatonin to which mink are exposed increase and are sufficient to promote changes in pelage growth as just described. It was generally assumed that melatonin acted directly on the hair follicle to evoke molting and regrowth. However the discovery that seasonal changes in daily systemic levels of PRL occurred that were inversely related to those of melatonin suggested the possibility that this protein hormone might actually mediate the apparent effect of melatonin on the pelage cycle. Indeed in mink the spring and autumn molts were found to be correlated with increasing and decreasing daily plasma concentrations of PRL respectively. Proof that photoperiod-related changes in prolactin secretion in mink are regulated at least in part by melatonin was provided by results of research demonstrating that the .

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