tailieunhanh - Báo cáo y học: "NGR1 single nucleotide polymorphisms in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis. | Available online http content 8 3 R63 Research article IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis Stefan Mattyasovszky1 2 4 Alla Skapenko1 2 Joachim R Kalden2 Peter E Lipsky3 and Hendrik Schulze-Koops1 2 1Nikolaus Fiebiger Center for Molecular Medicine Clinical Research Group III University of Erlangen Germany 2Department of Internal Medicine III University of Erlangen Germany 3National Institute of Arthritis and Musculoskeletal and Skin Diseases Bethesda Maryland USA 4Department of Trauma Surgery University of Mainz Germany Corresponding author Hendrik Schulze-Koops schulze-koops@ Received 30 Nov 2005 Revisions requested 6 Feb 2006 Revisions received 13 Feb 2006 Accepted 22 Feb 2006 Published 23 Mar 2006 Arthritis Research Therapy 2006 8 R63 doi ar1 927 This article is online at http content 8 3 R63 2006 Mattyasovszky et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract On the basis of their biological function potential genetic candidates for susceptibility to rheumatoid arthritis can be postulated. IFNGR1 encoding the ligand-binding chain of the receptor for interferon gamma IFNyR1 is one such gene because interferon gamma is involved in the pathogenesis of the disease. In the coding sequence of IFNGR1 two nucleotide positions have been described to be polymorphic in the Japanese population. We therefore investigated the association of those two IFNGR1 single nucleotide polymorphisms with rheumatoid arthritis in a case-control study in a central European population. Surprisingly however neither position was polymorphic in the 364 individuals examined indicating that IFNGR1 does not contribute to .