tailieunhanh - Báo cáo y học: "Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans? | Available online http content 8 2 106 Commentary Usurped SLRPs novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans Carl R Flannery Wyeth Research Cambridge MA USA Corresponding author Carl R Flannery cflannery@ Published 13 March 2006 Arthritis Research Therapy 2006 8 106 doi ar1925 This article is online at http content 8 2 106 2006 BioMed Central Ltd See related research by Monfort et al. in issue http content 8 1 R26 and Young et al. in issue http content 7 4 R852 Abstract Proteolytic degradation of articular cartilage macromolecules including the large aggregating cartilage proteoglycan aggrecan and small leucine-rich proteoglycans SLRPs is a prominent pathophysiological feature of arthritic diseases such as osteoarthritis OA . Molecular profiling and monitoring of soluble circulating proteoglycan catabolites that may be released from the cartilage matrix therefore represents an attractive strategy for evaluating OA disease progression and intervention. The recent identification of discrete metalloproteinase-sensitive SLRP cleavage sites and complementary neoepitope-bearing SLRP catabolites extends decisive insight into the functional regulation of extracellular matrix integrity and proffers poignant leads to assist in disclosing and appraising applicable biomarkers of cartilage degeneration during arthritis. Proficient operativity of articular cartilage is effectively maintained via the specialized qualities of multiple macromolecular components including a notable array of collagens and proteoglycans. Critical attributes of collagen organization and cytoregulatory sequelae are orchestrated in part through the interactive influences of a number of small leucine-rich proteoglycans SLRPs catabolism of which for example during osteoarthritis OA may thereby detrimentally alter the biological and biophysical .