tailieunhanh - Báo cáo y học: "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. | Available online http content 8 3 R55 Research article Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility case-control studies in Spanish Caucasians Julio Rodriguez-Lopez1 Manuel Pombo-Suarez1 Myriam Liz1 Juan J Gomez-Reino1 2 and Antonio Gonzalez1 1Laboratorio de Investigacion 2 and Rheumatology Unit Hospital Clinico Universitario de Santiago Santiago de Compostela Spain 2Department of Medicine University of Santiago de Compostela Spain Corresponding author Antonio Gonzalez anlugon@ Received 21 Dec 2005 Revisions requested 18 Jan 2006 Revisions received 3 Feb 2006 Accepted 14 Feb 2006 Published 10 Mar 2006 Arthritis Research Therapy 2006 8 R55 doi ar1920 This article is online at http content 8 3 R55 2006 Rodriguez-Lopez et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract A recent genetic association study has identified a microsatellite in the coding sequence of the asporin gene as a susceptibility factor for osteoarthritis OA . Alleles of this microsatellite determine the variable number of aspartic acid residues in the amino-terminal end of the asporin protein. Asporin binds directly to the growth factor transforming growth factor beta and inhibits its anabolic effects in cartilage which include stimulation of collagen and aggrecan synthesis. The OA-associated allele with 14 aspartic acid residues inhibits the anabolic effects of transforming growth factor beta more strongly than other asporin alleles leading to increased OA liability. We have explored whether the association found in several cohorts of Japanese hip OA and knee OA patients was also present in .

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