tailieunhanh - Báo cáo khoa học: "Management of gastrointestinal stromal tumours in the Imatinib era: a surgeon's perspective"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Management of gastrointestinal stromal tumours in the Imatinib era: a surgeon's perspective | BioMed Central World Journal of Surgical Oncology Research Management of gastrointestinal stromal tumours in the Imatinib era a surgeon s perspective Ravindra S Date f Nicholas A Stylianidesh Kishore G Pursnani Jeremy B Ward and Muntzer M Mughal Address Department of Gastrointestinal Surgery Lancashire Teaching Hospital NHS Foundation Trust Preston Road Chorley Lancashire PR7 1PP UK Email Ravindra S Date - ravidate@ Nicholas A Stylianides - nickstylianides@ Kishore G Pursnani - Jeremy B Ward - Muntzer M Mughal - muntzer@ Corresponding author tEqual contributors Open Access Published 18 July 2008 Received 9 March 2008 World Journal of Surgical Oncology 2008 6 77 doi 1477-7819-6-77 Accepted 18 July 2008 This article is available from http content 6 1 77 2008 Date et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Surgical resection has remained the mainstay of treatment of GIST with a 5-year-survival of 28-35 . Tyrosine kinase inhibitor Imatinib has revolutionised the treatment of these tumours. The current research is directed towards expanding the role of this drug in the treatment of GIST. We present our experience of managing GIST in this institute. Methods This is a case note study of patients identified from a prospectively kept database from January 2000 to August 2007. Results 16 patients were diagnosed with GIST. The median age was 66 years range 46 to 82 and the male to female ratio was 9 7. Eleven patients underwent surgery 9 of which had R0 resection 2 laparoscopic 1 converted to open one had an open biopsy and one had a debulking procedure. 3 patients were inoperable and 2 were found