tailieunhanh - Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis? | Available online http content 7 6 253 Review Dipeptidyl peptidase IV activity and or structure homologs Contributing factors in the pathogenesis of rheumatoid arthritis Aleksi Sedo1 Jonathan S Duke-Cohan2 Eva Balaziova1 and Liliana R Sedova3 1 Laboratory of Cancer Cell Biology of the 1st Faculty of Medicine Charles University Prague and the Institute of Physiology Academy of Sciences Prague Czech Republic 2Department of Medical Oncology Dana-Farber Cancer Institute and Department of Medicine Harvard Medical School Boston USA institute of Rheumatology Prague Czech Republic Corresponding authors Aleksi Sedo Aleksi@ Jonathan Duke-Cohan Jonathan_Duke-Cohan@ Published 26 October 2005 This article is online at http content 7 6 253 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 253-269 DOI ar1852 Abstract Several of the proinflammatory peptides involved in rheumatoid arthritis pathogenesis including peptides induced downstream of tumor necrosis factor-a as well as the monocyte T cell-attracting chemokines RANTES and stromal cell-derived factor SDF -1 a and the neuropeptides vasoactive intestinal peptide VIP and substance P have their biological half-lives controlled by dipeptidyl peptidase IV DPPIV . Proteolysis by DPPIV regulates not only the half-life but also receptor preference and downstream signaling. In this article we examine the role of DPPIV homologs including CD26 the canonical DPPIV and their substrates in the pathogenesis of rheumatoid arthritis. The differing specific activities of the DPPIV family members and their differential inhibitor response provide new insights into therapeutic design. Introduction A significant proportion of the biologically active peptides including systemic and locally acting neuropeptides lympho-kines cytokines and chemokines contain an evolutionarily conserved amino-terminal penultimate proline residue as a proteolytic-processing .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.