tailieunhanh - Báo cáo y học: "Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus. | Available online http content 8 2 R49 Research article Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus Lucrezia Colonna1 Joudy-Ann Dinnall1 Debra K Shivers1 Lorenza Frisoni2 Roberto Caricchio2 and Stefania Gallucci1 Open Access Laboratory of Dendritic Cell Biology Division of Rheumatology Joseph Stokes Jr. Research Institute Children s Hospital of Philadelphia 3615 Civic Center Boulevard Philadelphia PA 19104-4318 USA 2Division of Rheumatology School of Medicine University of Pennsylvania 751 BRB II III 421 Curie Blvd Philadelphia PA 19104 USA Corresponding author Stefania Gallucci gallucci@ Received 12 Dec 2005 Revisions requested 10 Jan 2006 Revisions received 31 Jan 2006 Accepted 2 Feb 2006 Published 28 Feb 2006 Arthritis Research Therapy 2006 8 R49 doi ar1911 This article is online at http content 8 2 R49 2006 Colonna et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We analyzed the activation and function of dendritic cells DCs in the spleens of diseased lupus-prone NZM2410 and NZB-W F1 mice and age-matched BALB c and C57BL 6 control mice. Lupus DCs showed an altered ex vivo costimulatory profile with a significant increase in the expression of CD40 decreased expression of CD80 and CD54 and normal expression of CD86. DCs from young lupus-prone NZM2410 mice before the development of the disease expressed normal levels of CD80 and CD86 but already overexpressed CD40. The increase in CD40-positive cells was specific for DCs and involved the subset of myeloid and CD8a DCs before disease onset with a small involvement of plasmacytoid DCs in diseased mice. In vitro data from .

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