tailieunhanh - Báo cáo y học: "It’s all in the blood: circulating endothelial progenitor cells link synovial vascularity with cardiovascular mortality in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: It’s all in the blood: circulating endothelial progenitor cells link synovial vascularity with cardiovascular mortality in rheumatoid arthritis? | Arthritis Research Therapy December 2005 Vol 7 No 6 Paleolog Viewpoint It s all in the blood circulating endothelial progenitor cells link synovial vascularity with cardiovascular mortality in rheumatoid arthritis Ewa Paleolog Kennedy Institute of Rheumatology Faculty of Medicine Imperial College Arthritis Research Campaign Building London UK Corresponding author Ewa Paleolog Published 27 October 2005 This article is online at http content 7 6 270 2005 BioMed Central Ltd The belief that there exists an undifferentiated cell which can be programmed into another type of cell forms the basis of stem cell biology as we know it today. This has opened up possibilities of new treatment approaches for a whole host of diseases. In the field of vascular biology there is also thought to be a renewable source of cells present in the adult that have the potential to develop along either the haematopoietic or the endothelial lineages. Fascinatingly recent studies have uncovered evidence suggesting that in rheumatoid arthritis RA such endothelial progenitor cells EPC are not only involved in synovial vascularisation but may also underlie the increased cardiovascular morbidity and mortality known to be a feature of RA thus linking two features of the disease that are well characterised but are as yet poorly understood. The notion that angiogenesis - the formation of new blood vessels from pre-existing vasculature - is important in the perpetuation of RA synovitis is no longer novel. There is ample evidence supporting this idea ranging from expression of proangiogenic factors such as vascular endothelial growth factor VEGF to studies in which inhibition of angiogenesis reduced the disease severity in animal models of arthritis 1 . However while the rheumatologic and scientific community is in all probability now quite familiar with angiogenesis and its role in RA pathogenesis the contribution made by EPC to blood vessel formation is