tailieunhanh - Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. | Available online http content 8 1 R1 Research article Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis a case-control study Julio Rodriguez-Lopez1 Eva Perez-Pampin1 Juan J Gomez-Reino1 2 and Antonio Gonzalez1 Research Laboratory 2 and Rheumatology Unit Hospital Clinico Universitario de Santiago Santiago de Compostela Spain 2Department of Medicine University of Santiago de Compostela Santiago de Compostela Spain Corresponding author Antonio Gonzalez Received 16 Aug 2005 Revisions requested 26 Sep 2005 Revisions received 3 Oct 2005 Accepted 10 Oct 2005 Published 1 Nov 2005 Arthritis Research Therapy 2006 8 R1 doi ar1849 This article is online at http content 8 1 R1 2005 Rodriguez-Lopez et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Many extracellular matrix ECM proteases seem to be important in rheumatoid arthritis RA and regulation of their transcription levels is a critical mechanism for controlling their activity. We have investigated therefore whether the best-characterized single nucleotide polymorphisms SNPs affecting transcription of the ECM proteases that have been related with joint pathology are associated with RA susceptibility. Nine SNPs in eight genes were selected by bibliographic search including SNPs in the genes encoding matrix metalloproteinase MMP 1 MMP2 MMP3 MMP7 MMP9 MMP13 plasminogen activator tissue type PLAT and PAI-1. They were studied in a casecontrol setting that included 550 RA patients and 652 controls of Spanish ancestry from a single center. Genotyping was performed by single-base extension. Only two of the nine .

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