tailieunhanh - Báo cáo khoa học: "bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study | BioMed Central World Journal of Surgical Oncology Research Open Access bcl-2 expression is not associated with survival in metastatic cutaneous melanoma A historical cohort study Marília B Espíndola 1 2 and Oly C Corleta1 2 Address 1Graduate Program in Medicine Surgery Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil and 2Rua Ramiro Barcelos 2300 Porto Alegre RS Brazil Email Marília B Espíndola - mariliae@ Oly C Corleta - oly@ Corresponding author Published 20 June 2008 Received 10 December 2007 World Journal of Surgical Oncology 2008 6 65 doi l477-78l 9-6-65 Accepted 20 June 2008 This article is available from http content 6 l 65 2008 Espíndola and Corleta licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Programmed cell death apoptosis has been implicated in tumor development and may affect the metastatic potential of tumor cells. The role of bcl-2 a proto-oncogene that inhibits apoptosis has been studied in several malignancies including cutaneous melanoma CM . The purpose of this study was to evaluate the immunohistochemical expression of bcl-2 in 35 regional lymph node 28 subcutaneous and 17 visceral CM metastases correlating the findings with patient survival. Methods In a historical cohort study patient survival was correlated with the expression of bcl-2 in regional lymph node subcutaneous and visceral metastases of CM. Eighty slides containing surgical specimens from 50 patients diagnosed with stage III and IV CM 28 male 56 and 22 female 44 were analyzed. Mean age at diagnosis was 43 years l6-74 years median 42 years . Mean Breslow depth was mm .