tailieunhanh - Báo cáo y học: " 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block. | Available online http content 8 1 R4 Research article 52-kDa Ro SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block Christine Fritsch1 Johan Hoebeke1 Hayet Dali1 Vincent Ricchiuti1 2 David A Isenberg3 Olivier Meyer4 and Sylviane Muller1 1UPR 9021 Centre National de la Recherche Scientifique Institut de Biologie Moléculaire et Cellulaire Strasbourg France 2Division of Endocrinology Diabetes Hypertension Brigham and Women s Hospital Harvard Medical School Boston MA USA 3Centre for Rheumatology The Middlesex Hospital University College London UK 4Groupe Hospitalier Bichat-Claude Bernard Service de Rhumatologie Paris France Corresponding author Sylviane Muller Received 24 Aug 2005 Revisions requested 22 Sep 2005 Revisions received 30 Sep 2005 Accepted 6 Oct 2005 Published 4 Nov 2005 Arthritis Research Therapy 2006 8 R4 doi ar1848 This article is online at http content 8 1 R4 2005 Fritsch et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro SSA antigen Ro52 ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances mainly congenital heart block. The objective of this study was to identify putative Ro52 60-kDa Ro SSA antigen Ro60 epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjogren s .

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