tailieunhanh - Báo cáo khoa học: "The significance of the Van Nuys prognostic index in the management of ductal carcinoma in situ"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The significance of the Van Nuys prognostic index in the management of ductal carcinoma in situ | BioMed Central World Journal of Surgical Oncology Research The significance of the Van Nuys prognostic index in the management of ductal carcinoma in situ Onur Gilleard Andrew Goodman Martin Cooper Mary Davies and Julie Dunn Open Access Address The Royal Devon and Exeter Breast Cancer Unit Exeter Devon EX2 5DW UK Email Onur Gilleard - onurgilleard@ Andrew Goodman - Martin Cooper - Mary Davies - Julie Dunn - Corresponding author Published 18 June 2008 Received 20 December 2007 World Journal of Surgical Oncology 2008 6 61 doi l477-78l 9-6-61 Accepted 18 June 2008 This article is available from http content 6 l 6l 2008 Gilleard et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Debate regarding the benefit of radiotherapy after local excision of ductal carcinoma in situ DCIS continues. The Van Nuys Prognostic Index VNPI is thought to be a useful aid in deciding which patients are at increased risk of local recurrence and who may benefit from adjuvant radiotherapy RT . Recently published interim data from the Sloane project has showed that the VNPI score did significantly affect the chances of getting planned radiotherapy in the UK suggesting that British clinicians may already be using this scoring system to assist in decision making. This paper independently assesses the prognostic validity of the VNPI in a British population. Patients and methods A retrospective review was conducted of all patients n 215 who underwent breast conserving surgery for DCIS at a single institution between l997 - 2006. No patients included in the study received additional radiotherapy or hormonal .