tailieunhanh - Báo cáo y học: "Association between anti-nucleophosmin and anti-cardiolipin antibodies in (NZW × BXSB)F1 mice and human systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association between anti-nucleophosmin and anti-cardiolipin antibodies in (NZW × BXSB)F1 mice and human systemic lupus erythematosus. | Available online http content 7 6 R1394 Research article Association between anti-nucleophosmin and anti-cardiolipin antibodies in NZW X BXSB F1 mice and human systemic lupus erythematosus Aurelia Lartigue1 Laurent Drouot1 Fabienne Jouen2 Roland Charlionet1 Frangois Tron1 2 and Danièle Gilbert1 2 1INSERM U519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides Faculte de Médecine et Pharmacie 22 boulevard Gambetta 76183 Rouen Cedex France 2Laboratoire d lmmunopathologie Clinique et Expérimentale CHU de Rouen 1 rue de Germont 76000 Rouen cedex France Corresponding author Frangois Tron Received 8 Jun 2005 Revisions requested 18 Jul 2005 Revisions received 11 Aug 2005 Accepted 9 Sep 2005 Published 13 Oct 2005 Arthritis Research Therapy 2005 7 R1394-R1403 DOI ar1838 This article is online at http content 7 6 R1394 2005 Lartigue et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract We showed previously that nucleophosmin NPM a nucleolar phosphoprotein is recognized by sera from NZW X BXSB F1 WB mice a model of systemic lupus erythematosus SLE and anti-phospholipid syndrome. In the present study we analysed the prevalence and kinetics of anti-NPM autoantibodies in WB mice by a solid-phase ELISA with recombinant human rh NPM as the antigen and showed that most male WB mouse sera had anti-NPM antibodies that were responsible for their indirect immunofluorescence staining pattern on Hep-2 cells. Anti-NPM antibodies were significantly associated with anti-cardiolipin aCL antibodies. This antibody profile mirrored that observed in certain human SLE sera because anti-NPM antibodies were detected in 28 of the sera .