tailieunhanh - Báo cáo y học: "Inflammation causes tissue-specific depletion of vitamin B6"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inflammation causes tissue-specific depletion of vitamin B6. | Available online http content 7 6 R1254 Research article Inflammation causes tissue-specific depletion of vitamin B6 En-Pei Chiang1 Donald E Smith2 Jacob Selhub3 Gerard Dallal4 Yi-Cheng Wang1 and Ronenn Roubenoff5 Open Access Department of Food Science and Biotechnology National Chung Hsing University Taichung Taiwan 2Comparative Biology Unit Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University Boston MA USA 3Vitamin Metabolism and Aging Laboratory JS New England Medical Center Boston MA USA 4Biostatistics Unit GD New England Medical Center Boston MA USA 5Nutrition Exercise Physiology and Sarcopenia Laboratory New England Medical Center Boston MA USA Corresponding author En-Pei Chiang chiangisabel@ Received 4 May 2005 Revisions requested 4 Jul 2005 Revisions received 2 Aug 2005 Accepted 15 Aug 2005 Published 13 Sep 2005 Arthritis Research Therapy 2005 7 R1254-R1262 DOI ar1821 This article is online at http content 7 6 R1254 2005 Chiang et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Previously we observed strong and consistent associations between vitamin B6 status and several indicators of inflammation in patients with rheumatoid arthritis. Clinical indicators including the disability score the length of morning stiffness and the degree of pain and biochemical markers including the erythrocyte sedimentation rate and C-reactive protein levels were found to be inversely correlated with circulating vitamin B6 levels. Such strong associations imply that impaired vitamin B6 status in these patients results from inflammation. In the present study we examined whether inflammation directly alters vitamin B6 tissue contents and its