tailieunhanh - Báo cáo y học: "Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technolog"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology. | Available online http content 8 2 R47 Research article Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology Johan Lindberg1 Erik af Klint2 Ann-Kristin Ulfgren2 André Stark3 Tove Andersson1 Peter Nilsson1 Lars Klareskog2 and Joakim Lundeberg1 Department of Biotechnology AlbaNova University Center Royal Institute of Technology S-106 91 Stockholm Sweden 2Department of Rheumatology Karolinska Institutet Karolinska University Hospital 171 76 Stockholm Sweden 3Department of Orthopedics Karolinska University Hospital 171 76 Stockholm Sweden Corresponding author Joakim Lundeberg Received 3 Jul 2005 Revisions requested 9 Sep 2005 Revisions received 18 Nov 2005 Accepted 23 Jan 2006 Published 16 Feb 2006 Arthritis Research Therapy 2006 8 R47 doi ar1 903 This article is online at http content 8 2 R47 2006 Lindberg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract In recent years microarray technology has been used increasingly to acquire knowledge about the pathogenic processes involved in rheumatoid arthritis. The present study investigated variations in gene expression in synovial tissues within and between patients with rheumatoid arthritis. This was done by applying microarray technology on multiple synovial biopsies obtained from the same knee joints. In this way the relative levels of intra-patient and inter-patient variation could be assessed. The biopsies were obtained from 13 different patients 7 by orthopedic surgery and 6 by rheumatic arthroscopy. The data show that levels of heterogeneity varied substantially between the biopsies because the number of genes found to be