tailieunhanh - Báo cáo y học: "Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure. | Available online http content 8 2 R46 Research article Methotrexate in rheumatoid arthritis is frequently effective even if re-employed after a previous failure Theresa Kapral1 Tanja Stamm1 Klaus P Machold1 Karin Montag2 Josef S Smolen1 2 and Daniel Aletaha1 3 1Department of Rheumatology Internal Medicine III Medical University of Vienna Vienna Austria 22nd Department of Medicine Lainz Hospital Vienna Austria 3National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda Maryland USA Corresponding author Daniel Aletaha aletahad@ Received 5 Oct 2005 Revisions requested 2 Dec 2005 Revisions received 28 Dec 2005 Accepted 23 Jan 2006 Published 24 Feb 2006 Arthritis Research Therapy 2006 8 R46 doi ar1902 This article is online at http content 8 2 R46 2006 Kapral et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Effectiveness of therapy with individual disease-modifying antirheumatic drugs DMARDs in rheumatoid arthritis RA is limited and the number of available DMARDs is finite. Therefore at some stage during the lengthy course of RA institution of traditional DMARDs that have previously been applied may have to be reconsidered. In the present study we investigated the effectiveness of re-employed methotrexate in patients with a history of previous methotrexate failure original course . A total of 1 490 RA patients 80 female 59 rheumatoid factor positive were followed from their first presentation yielding a total of 6 470 patient-years of observation. We identified patients in whom methotrexate was re-employed after at least one intermittent course of a different DMARD. We compared reasons .