tailieunhanh - Báo cáo y học: "dentification of collagen-induced arthritis loci in aged multiparous female mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Identification of collagen-induced arthritis loci in aged multiparous female mice. | Available online http content 8 2 R45 Research article Identification of collagen-induced arthritis loci in aged multiparous female mice Maria Liljander1 Mary-Ann Sallstrom1 Sara Andersson1 Ảsa Andersson2 Rikard Holmdahl3 and Ragnar Mattsson1 1Lund Transgenic Core Facility Lund University Lund Sweden 2Department of Pharmacology The Danish University of Pharmaceutical Sciences Copenhagen Denmark 3Medical Inflammation Research Lund University Lund Sweden Corresponding author Maria Liljander Received 17 Oct 2005 Revisions requested 21 Dec 2005 Revisions received 17 Jan 2006 Accepted 19 Jan 2006 Published 14 Feb 2006 Arthritis Research Therapy 2006 8 R45 doi ar1 901 This article is online at http content 8 2 R45 2006 Liljander et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR N and H-2q haplotype . The mice in the present study had different reproductive histories which did not significantly affect the onset incidence or severity of the disease. A total of 200 female mice were used in a total genome wide screening with 125 microsatellite markers. We found one new significant quantitative trait locus affecting the arthritis .