tailieunhanh - Báo cáo y học: "Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. | Available online http content 7 6 R1227 Research article Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis John R Glossop Peter T Dawes Nicola B Nixon and Derek L Mattey Staffordshire Rheumatology Centre University Hospital of North Staffordshire Stoke-on-Trent UK Corresponding author Derek L Mattey Received 17 Mar 2005 Revisions requested 25 Apr 2005 Revisions received 28 Jul 2005 Accepted 10 Aug 2005 Published 7 Sep 2005 Arthritis Research Therapy 2005 7 R1227-R1 234 DOI ar1816 This article is online at http content 7 6 R1227 2005 Glossop et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Levels of soluble tumour necrosis factor receptors sTNFRs are elevated in the circulation of patients with rheumatoid arthritis RA . Although these receptors can act as natural inhibitors of tumour necrosis factor-a levels of sTNFRs in RA appear to be insufficient to prevent tumour necrosis factor-a induced inflammation. The factors that regulate circulating levels of sTNFRs are unclear but polymorphisms in the tumour necrosis factor receptor genes may play a role. We investigated the relationship between polymorphisms in the tumour necrosis factor receptor I TNF-RI and II TNF-RII genes and levels of sTNFRs in two groups of Caucasian RA patients one with early disease duration 2 years n 103 and one with established disease disease duration 5 years n 151 . PCR restriction fragment length polymorphism analysis was used to genotype patients for the A36G polymorphism in the TNF-RI gene and the T676G polymorphism in TNF-RII. .