tailieunhanh - Báo cáo y học: "CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes. | Available online http content 8 2 R44 Research article CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes Ping Zhu1 Ning Lu1 Zhan-guo Shi1 Jun Zhou2 Zhen-biao Wu1 Yong Yang1 Jin Ding1 and Zhi-nan Chen2 Open Access Department of Clinical Immunology Xijing Hospital Fourth Military Medical University Xi an 710032. Shaanxi Province PR China 2Cell Engineering Research Center Department of Cell Biology Fourth Military Medical University Xi an 710032 Shaanxi Province PR China Corresponding author Zhi-nan Chen chcerc2@ Received 9 Sep 2005 Revisions requested 13 Oct 2005 Revisions received 30 Dec 2005 Accepted 16 Jan 2006 Published 8 Feb 2006 Arthritis Research Therapy 2006 8 R44 doi ar1 899 This article is online at http content 8 2 R44 2006 Zhu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Macrophage-like synoviocytes and fibroblast-like synoviocytes FLS are known as the most active cells of rheumatoid arthritis RA and are close to the articular cartilage in a position enabling them to invade the cartilage. Macrophage-like synoviocytes and FLS expression of matrix metalloproteinases MMPs and their interaction has aroused great interest. The present article studied the expression of CD147 also called extracellular matrix metalloproteinase inducer on monocytes macrophages and FLS from RA patients and its potential role in enhancing MMPs and the invasiveness of synoviocytes. Expression of CD147 on FLS derived from RA patients and from osteoarthritis patients and expression of CD147 on monocytes macrophages from rheumatic synovial fluid and healthy peripheral blood .