tailieunhanh - Báo cáo y học: "Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis. | Available online http content 7 4 R868 Research article Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis Philip Gierer1 2 Saleh Ibrahim3 Thomas Mittlmeier1 Dirk Koczan3 Steffen Moeller3 Jurgen Landes4 Georg Gradl1 2 and Brigitte Vollmar1 Open Access Department of Experimental Surgery University of Rostock Rostock Germany department of Trauma Reconstructive Surgery University of Rostock Rostock Germany 3Institute of Immunology University of Rostock Rostock Germany department of Surgery Klinikum Innenstadt Ludwig Maximilians University Munich Germany Corresponding author Brigitte Vollmar Received 10 Mar 2005 Accepted 13 Apr 2005 Published 1 7 May 2006 Arthritis Research Therapy 2005 7 R868-R876 DOI 86 ar1 754 This article is online at http content 7 4 R868 2005 Gierer et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial microcirculation of knee joints in susceptible mouse strains undergoing intradermal immunization with bovine collagen II in complete Freund s adjuvant to induce arthritis . collagen-induced arthritis CIA . Susceptible DBA1 J and collagen II T-cell receptor transgenic mice were compared with CIA-resistant FVB NJ mice. Before onset of clinical symptoms of arthritis in vivo fluorescence microscopy of knee joints revealed marked leucocyte activation and interaction with the endothelial lining of synovial microvessels. This initial inflammatory cell response correlated with the gene expression