tailieunhanh - Báo cáo y học: "Elimination of rheumatoid synovium in situ using a Fas ligand 'gene scalpel"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Elimination of rheumatoid synovium in situ using a Fas ligand 'gene scalpel'. | Available online http content 7 6 R1235 Research article Elimination of rheumatoid synovium in situ using a Fas ligand gene scalpel Haidi Zhang1 Guangping Gao2 Gilda Clayburne3 and H Ralph Schumacher2 3 Division of Pharmaceutics and Industry Pharmacy School of Pharmacy Long Island University Brooklyn NY USA 2Department of Medicine School of Medicine University of Pennsylvania Philadelphia PA USA 3Veterans Affairs Medical Center in Philadelphia Philadelphia PA USA Corresponding author Haidi Zhang Received 14 Sep 2004 Revisions requested 1 Nov 2004 Revisions received 29 Jul 2005 Accepted 3 Aug 2005 Published 8 Sep 2005 Arthritis Research Therapy 2005 7 R1235-R1243 DOI ar1811 This article is online at http content 7 6 R1 235 2005 Zhang et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Surgical synovectomy to remove the inflammatory synovium can temporarily ameliorate rheumatoid inflammation and delay the progress of joint destruction. An efficient medically induced programmed cell death apoptosis in the rheumatoid synovium might play a role similar to synovectomy but without surgical tissue damage. Gene transfer of Fas ligand FasL has increased the frequency of apoptotic cells in mouse and rabbit arthritic synovium. In this study we investigated whether repeated FasL gene transfer could remove human inflammatory synovial tissue in situ and function as a molecular synovectomy. Briefly specimens of human synovium from joint replacement surgeries and synovectomies of rheumatoid arthritis RA patients were grafted subcutaneously into male severe combined immunodeficiency SCID mice. Injections of a recombinant FasL adenovirus .

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