tailieunhanh - Báo cáo y học: "Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen. | Available online http content 7 5 R1148 Research article Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen Estelle Bajtner1 Kutty S Nandakumar1 Ảke Engstrom2 and Rikard Holmdahl1 1Medical Inflammation Research Lund University Lund Sweden 2Uppsala Biomedical Center IMBIM Uppsala Sweden Corresponding author Rikard Holmdahl Received 7 Jun 2005 Revisions requested 27 Jun 2005 Revisions received 1 Jul 2005 Accepted 8 Jul 2005 Published 27 Jul 2005 Arthritis Research Therapy 2005 7 R1148-R1157 DOI ar1800 This article is online at http content 7 5 R1148 2005 Bajtner et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Antibodies against type II collagen CII are important in the development of collagen-induced arthritis CIA and possibly also in rheumatoid arthritis. We have determined the fine specificity and arthritogenicity of the antibody response to CII in chronic relapsing variants of CIA. Immunization with rat CII in or BALB F2 mice induces a chronic relapsing CIA. The antibody response to CII was determined by using triple-helical peptides of the major B cell epitopes. Each individual mouse had a unique epitope-specific response and this epitope predominance shifted distinctly during the course of the disease. In the mice the antibodies specific for C1 and U1 and in the BALB F2 mice the antibodies specific for C1 U1 and J1 correlated with the development of chronic arthritis. Injection of monoclonal antibodies against these epitopes induced relapses in chronic arthritic mice. The development of .

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