tailieunhanh - Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of regulatory T cells in experimental arthritis and implications for clinical use. | Arthritis Research Therapy June 2005 Vol 7 No 3 Londei Commentary Role of regulatory T cells in experimental arthritis and implications for clinical use Marco Londei Institute of Child Health University College London London UK Corresponding author Marco Londei Published 7 April 2005 Arthritis Research Therapy 2005 7 118-120 DOI ar1745 This article is online at http content 7 3 118 2005 BioMed Central Ltd See related research by Frey et al. in issue page 90 http content 7 2 R291 Abstract CD4 CD25 T regulatory cells are avidly studied because they modulate immune responses. Their possible role in autoimmunity and more specifically in rheumatoid arthritis RA has been highlighted by a string of reports one of which is in the last issue of Arthritis Research Therapy. There are however key questions that have not yet been addressed before their use can be considered as a real therapeutic option. The first is the actual in a clinical setting efficacy of Treg to treat active chronic autoimmune diseases such as RA. The second is how we can practically deliver their therapeutic activity in patients. Once these points have been addressed we will have a new and potentially very effective magic bullet for the treatment of chronic autoimmune diseases. In recent years the T-regulatory CD4 CD25 Treg storm has remodelled the immunology landscape. Since the original reports of a suppressive activity of CD4 CD25 Treg in the mid-1980s an exponential number of papers have appeared in the literature. The employment of CD4 CD25 Treg for therapeutic purposes is now one of the holy grails in immunology and much effort is focused on the exploitation of this therapeutic avenue. In the last issue of Arthritis Research Therapy Frey and colleagues 1 provide an additional piece to the CD4 CD25 Treg jigsaw. In most autoimmune diseases in humans or in animal models Treg have been identified 2 3 . In all tested models

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