tailieunhanh - Báo cáo y học: "Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period. | Available online http content 8 1 R29 Open Access Research article Switching TNF antagonists in patients with chronic arthritis an observational study of 488 patients over a four-year period Juan J Gomez-Reino1 Loreto Carmona2 and the BIOBADASER Group3 Rheumatology Service and Department of Medicine Hospital Clinico Universitario Medical School Universidad de Santiago de Compostela Spain 2Unidad de Investigacion Sociedad Espanola de Reumatologia Madrid Spain 3A list of participating investigators and centers appears in Acknowledgements Corresponding author Juan J Gomez-Reino Received 20 Jul 2005 Revisions requested 7 Sep 2005 Revisions received 7 Oct 2005 Accepted 8 Dec 2005 Published 6 Jan 2006 Arthritis Research Therapy 2006 8 R29 doi ar1 881 This article is online at http content 8 1 R29 2006 Gomez-Reino and Loreto Carmona licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The objective of this work is to analyze the survival of infliximab etanercept and adalimumab in patients who have switched among tumor necrosis factor TNF antagonists for the treatment of chronic arthritis. BIOBADASER is a national registry of patients with different forms of chronic arthritis who are treated with biologics. Using this registry we have analyzed patient switching of TNF antagonists. The cumulative discontinuation rate was calculated using the actuarial method. The log-rank test was used to compare survival curves and Cox regression models were used to assess independent factors associated with discontinuing medication. Between February 2000 and September 2004 4 706 patients were registered in BIOBADASER of whom 68 had rheumatoid arthritis 11

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.