tailieunhanh - Báo cáo y học: "Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides. | Available online http content 7 5 R1072 Research article Antineutrophil cytoplasmic antibody ANCA -associated autoimmune diseases induced by antithyroid drugs comparison with idiopathic ANCA vasculitides Branka Bonaci-Nikolic1 Milos M Nikolic2 Sladjana Andrejevic1 Svetlana Zoric3 and Mirjana Bukilica4 Institute of Allergy and Clinical Immunology Clinical Centre of Serbia Belgrade Serbia and Montenegro institute of Dermatology Clinical Centre of Serbia Belgrade Serbia and Montenegro institute of Endocrinology Clinical Centre of Serbia Belgrade Serbia and Montenegro 4Institute of Rheumatology Belgrade Serbia and Montenegro Corresponding author Branka Bonaci-Nikolic branka_bonaci@ Received 28 Apr 2005 Revisions requested 25 May 2005 Revisions received 14 Jun 2005 Accepted 22 Jun 2005 Published 13 Jul 2005 Arthritis Research Therapy 2005 7 R1072-R1081 DOI ar1789 This article is online at http content 7 5 R1072 2005 Bonaci-Nikolic et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Clinical and serological profiles of idiopathic and drug-induced autoimmune diseases can be very similar. We compared data from idiopathic and antithyroid drug ATD -induced antineutrophil cytoplasmic antibody ANCA -positive patients. From 1993 to 2003 2474 patients were tested for ANCA in the Laboratory for Allergy and Clinical Immunology in Belgrade. Out of 2474 patients 72 were anti-proteinase 3 PR3 - or anti-myeloperoxidase MPO -positive and their clinical and serological data were analyzed. The first group consisted of ANCA-associated idiopathic systemic vasculitis ISV diagnosed in 56 72 patients 29 Wegener s granulomatosis WG 23 microscopic polyangiitis MPA