tailieunhanh - Báo cáo y học: "Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. | Available online http content 7 4 R796 Research article Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis validation of a clinical activity score Daniel Aletaha1 2 Valerie PK Nell1 Tanja Stamm1 Martin Uffmann3 Stephan Pflugbeil4 Klaus Machold1 and Josef S Smolen1 4 Open Access Department of Rheumatology Medical University of Vienna Vienna Austria 2National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda Maryland USA department of Radiology Medical University of Vienna Vienna Austria 42nd Department of Medicine Lainz Hospital Vienna Austria Corresponding author Daniel Aletaha aletahad@ Received 15 Dec 2004 Revisions requested 7 Feb 2005 Revisions received 16 Feb 2005 Accepted 10 Mar 2005 Published 7 Apr 2005 Arthritis Research Therapy 2005 7 R796-R806 DOI 86 ar1 740 This article is online at http content 7 4 R796 2005 Aletaha et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Frequent assessments of rheumatoid arthritis RA disease activity allow timely adaptation of therapy which is essential in preventing disease progression. However values of acute phase reactants APRs are needed to calculate current composite activity indices such as the Disease Activity Score DaS 28 the DAS28-CRP . the DAS28 using C-reactive protein instead of erythrocyte sedimentation rate and the Simplified Disease Activity Index SDAI . We hypothesized that APRs make limited contribution to the SDAI and that an SDAI-modification eliminating APRs - termed the Clinical Disease Activity Index CDAI . the sum of tender and swollen joint counts 28 joints and patient .